Following are the top-grossing science fiction, fantasy, horror and spy-fi films of 2008.
| Rank | Overall | Title | Gross (in millions) |
Budget (in millions) |
| 1. | 1. | The Dark Knight | $1,001 US: $533 |
$185 |
| 2. | 2. | Indiana Jones and the Kingdom of the Crystal Skull | $787 US: $317 |
$185 |
| 3. | 3. | Kung Fu Panda | $632 US: 417 |
$130 |
| 4. | 4. | Hancock | $624 US: $396 |
$150 |
| 5. | 6. | Madagascar: Escape 2 Africa | $591 US: $180 |
$150 |
| 6. | 7. | Iron Man | $582 US: $318 |
$140 |
| 7. | 9. | WALL-E | $535 $US: 224 |
$180 |
| 8. | 10. | The Chronicles of Narnia: Prince Caspian | $420 US: $141M |
$200 |
| 9. | 12. | The Mummy: Tomb of the Dragon Emperor | $401 US: $103 |
$145 |
| 10. | 13. | Twiight | $377 US: $192 |
$37 |
| 11. | 14. | Wanted | $341 US: $135 |
$75 |
| 12. | 15. | The Curious Case of Benjamin Button | $329 US: $127 |
$150 |
| 13. | 17. | Dr. Seuss’ Horton Hears a Who! | $297 US: $155 |
$85 |
| 14. | 18. | Bolt | $287 US: $114 |
$150 |
| 15. | 19. | 10,000 B.C. | $270 US: $95 |
$105 |
| 16. | 20. | The Incredicle Hulk | $263 US: $135 |
$150 |
| 17. | 22. | Journey to the Center of the Earth | $242 US: $102 |
$60 |
| 18. | 23. | The Day the Earth Stood Still | $231 US: $79 |
$80 |
| 19. | 24. | Get Smart | $230 US: $130 |
$80 |
| 20. | 26. | Jumper | $222 US: $80 |
$85 |
| 21. | 30. | Bedtime Stories | $209 US: $110 |
$80 |
| 22. | 36. | Cloverfield | $171 US: $80 |
$25 |
| 23. | 39. | The Happening | $164 US: $65 |
$48 |
| 24. | 40. | The Spiderwick Chronicles | $163 US: $71 |
$90 |
| 25. | 41. | Hellboy II: The Golden Army | $160 US: $76 |
$85 |
| 26. | 47. | Beverly Hills Chihuahua | $141 US: $95 |
N/A |
| 27. | 48. | The Forbidden Kingdom | $129 US: $52 |
N/A |
| 28. | 59. | Nim’s Island | $100 US: $48 |
$37 |
| 29. | 60. | Speed Racer | $94 US: $44 |
$120 |
| 30. | 63. | Max Payne | $85 US: $41 |
$35 |
| 31. | 64. | The Tale of Despereaux | $84 US: $51 |
$60 |
| 32. | 70. | Mirrors | $76 US: $31 |
N/A |
| 33. | 72. | Death Race | $75 US: $36 |
$45 |
| 34. | 74. | Babylon A.D. | $72 US: $23 |
$70 |
| 35. | 75. | Superhero Movie | $71 US: $26 |
N/A |
| 36. | 78. | The X-Files: I Want to Believe | $69 US: $21 |
$30 |
| 37. | 79. | Star Wars: The Clone Wars | $68 US: $35 |
N/A |
| 38. | 81. | Space Chimps | $65 US: $30 |
$37 |
| 39. | 85. | The Eye | $57 US: $31 |
N/A |
| 40. | 94. | Shutter | $48 US: $26 |
N/A |
| 41. | 95. | CJ7 | $47 US: $0.2 |
N/A |
| 42. | 96. | One Missed Call | $46 US: $27 |
$20 |
| 43. | 105. | Quarantine | $41 US: $32 |
$12 |
| 44. | 114. | The Spirit | $38 US: $20 |
N/A |
| 45. | 115. | Fly Me to The Moon | $38 US: $13 |
$25 |
| 46. | 129. | Igor | $30 US: $20 |
$25 |
| 47. | 134. | Ghost Town | $27 US: $13 |
$20 |
| 48. | 144. | The Ruins | $23 US $17 |
N/A |
| 49. | 146. | Doomsday | $22 US: $11 |
N/A |
| 50. | 148. | Over Her Dead Body | $21 US $8 |
N/A |
Source: Box Office Mojo